The NCBI RefSeq database is a collection of taxonomically diverse, non-redundant and richly annotated sequences from high quality closed genomes (reference datasets), 1,942 as of March 2018. By searching genomes against this database, users can begin to understand their datasets. MiGA will identify closely related sequences which are annotated in the RefSeq database. Thus, RefSeq analysis is best suited to identify the closest related high-quality available genomes.